Trial of solanezumab for mild dementia due to Alzheimer's disease. Advances in developing novel therapeutic strategies for Alzheimer's disease. Emerging mechanisms in Alzheimer's disease and their therapeutic implications. Development of a unified clinical trial database for Alzheimer's disease. MIND diet associated with reduced incidence of Alzheimer's disease. Prevention and risk of Alzheimer's and dementia.Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2015 1:111. Delayed-start analysis: Mild Alzheimer's disease patients in solanezumab trials, 3.5 years. Randomized trial of verubecestat for mild-to-moderate Alzheimer's disease. Novel strategies for Alzheimer's disease treatment: An overview of anti-amyloid beta monoclonal antibodies. American Journal of Geriatric Psychiatry. Current and future treatments for Alzheimer disease. Recent studies showed that the beta-secretase inhibitors did not slow down cognitive decline and were associated with significant side effects in those with mild or moderate Alzheimer's, which has decreased enthusiasm for this mechanism of drug. They're known as beta- and gamma-secretase inhibitors. Several experimental drugs aim to block the activity of these enzymes. Research has shown that beta-amyloid is produced from a "parent protein" in two steps performed by different enzymes. These therapies may reduce the amount of beta-amyloid formed in the brain. Human trials for saracatinib as a possible Alzheimer's disease treatment are now underway. In mice, the drug turned off a protein that allowed synapses to start working again, and the animals experienced a reversal of some memory loss. A drug initially developed as a possible cancer treatment - saracatinib - is now being tested in Alzheimer's disease. The drug seemed safe in recent studies, and solanezumab continues to be evaluated in the preclinical stage of the disease. It's possible that solanezumab may be more effective when given earlier in the course of the disease. In studies, the monoclonal antibody solanezumab did not demonstrate any benefit for individuals with mild or moderate Alzheimer's disease. The medicine has moved into a phase 3 study. Another study is looking at how effective the medicine may be for people at risk of Alzheimer's disease, including people who have a first-degree relative, such as a parent or sibling, with the disease.ĭonanemab, another monoclonal antibody, also has shown promise. This study was the largest so far to look at whether clearing clumps of amyloid plaques from the brain can slow the disease. Lecanemab works by preventing amyloid plaques in the brain from clumping. It could become available in 2023.Ī phase 3 clinical trial found that the medicine slowed cognitive decline in people with early Alzheimer's disease by 27%. But it hasn't been widely used because studies about its effectiveness at slowing cognitive decline are mixed and coverage is limited.Īnother Alzheimer's medicine, lecanemab, has shown promise for people with mild Alzheimer's disease and mild cognitive impairment due to Alzheimer's disease. The medicine was approved in the United States because it removes amyloid plaques in the brain. The medicine was studied in people living with early Alzheimer's disease, including people with mild cognitive impairment due to Alzheimer's disease. In June 2021, the Food and Drug Administration (FDA) approved aducanumab (Aduhelm) for the treatment of some cases of Alzheimer's disease.
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